n a congenital defect in which the top of the head is depressed (concave instead of convex)
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n a congenital defect in which one or more toes or fingers are abnormally positioned
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n a congenital defect of the central nervous system in which a sac containing part of the spinal cord and its meninges protrude through a gap in the vertebral column
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n congenital defect of having one or more extra chromosomes in somatic cells
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n a not uncommon congenital defect in which a vertebra is malformed